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Related Experiment Video

Updated: Dec 9, 2025

Quantifying the Binding Interactions Between CuII and Peptide Residues in the Presence and Absence of Chromophores

Quantifying the Binding Interactions Between CuII and Peptide Residues in the Presence and Absence of Chromophores

Published on: April 5, 2022

Aβ_5- Peptides: N-Terminal Truncation Yields Tunable Cu(II) Complexes.

Nina E Wezynfeld¹, Aleksandra Tobolska^1,2, Mariusz Mital³

¹Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.

Inorganic Chemistry

|September 14, 2020

Summary

Amyloid-beta (Aβ)_5- peptides bind copper(II) ions with high affinity, potentially impacting copper handling in Alzheimer's disease. These findings highlight Aβ_5- peptides as significant players in copper dyshomeostasis.

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Last Updated: Dec 9, 2025

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Published on: April 5, 2022

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Thermochemical Studies of NiII and ZnII Ternary Complexes Using Ion Mobility-Mass Spectrometry

Thermochemical Studies of NiII and ZnII Ternary Complexes Using Ion Mobility-Mass Spectrometry

Published on: June 8, 2022

Area of Science:

Biochemistry
Coordination Chemistry
Neuroscience

Background:

Amyloid-beta (Aβ)_5- peptides are minor species in normal brains but increase with enzyme inhibitors.
They possess an Arg-His metal-binding sequence, forming a 3-nitrogen (3N) chelate system capable of binding Cu(II).

Purpose of the Study:

To investigate Cu(II) complex formation and reactivity of truncated Aβ_5- peptide models.
To understand the role of these peptides in copper handling and potential implications for Alzheimer's disease.

Main Methods:

Circular Dichroism (CD) spectroscopy
UV-visible (UV-vis) spectroscopy
Potentiometry

Main Results:

All tested peptides (Aβ_5-9, Aβ_5-12, Aβ_5-12Y10F, Aβ_5-16) coordinated Cu(II) with high affinities (>3 × 10¹² M^-1 at pH 7.4).
Aβ_5-16 showed a 3-fold increase in affinity due to internal macrochelation.
Cu-Aβ_5- complexes could be reduced to Cu(I) and oxidized to Cu(III), with imidazole coordination influencing redox stability.

Conclusions:

Aβ_5- peptides bind Cu(II) strongly, more so than Aβ_1- peptides.
These peptides may interfere with copper handling, contributing to copper dyshomeostasis in Alzheimer's disease brains.