Enantioselective Total Synthesis of Mollebenzylanol A
Yuichiro Kawamoto1, Fuka Karube1, Toyoharu Kobayashi1
1School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Abstract:
Mollebenzylanol A is a tyrosine phosphatase 1B inhibitor isolated from the leaves of Rhododendron molle in 2018 that has a highly functionalized structure. The first enantioselective total synthesis of mollebenzylanol A was achieved in 13 steps from a known chiral starting material. An efficient and practical synthetic scheme was disclosed in a stereocontrolled manner, including stereo/regioselective epoxidation, Eschenmoser-Claisen rearrangement, and stereocontrolled dihydroxylation.
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