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Updated: Dec 9, 2025

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Trichocladabiflavone A, a chalcone-flavonone type biflavonoid from Selaginella trichoclada Alsto
Yang Xie1, Xiao-Chang Yao2, Lei-Hong Tan3
1Phase I Clinical Trial Center, Xiangya Hospital, Central South University, Changsha, PR China.
Abstract:
A chalcone-flavonone type biflavonoid, trichocladabiflavone A (1), along with eight known biflavonoids (2-9) were isolated from the 70% EtOH extract of Selaginella trichoclada. Their structures were elucidated by extensive spectroscopic analyses. Compound 1 was the first chalcone-flavonone type biflavonoid reported in the genus Selaginella. Moreover, compound 1 exhibited moderate cytotoxicity against DU145, MCF-7 and PC3 human cancer cell lines.
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