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Exosomes-based cell-free cancer therapy: a novel strategy for targeted therapy

Abhishek Dutta1

  • 1Independent Author, Kolkata, West Bengal, India.

Immunological Medicine
|September 14, 2020
PubMed

Insights

Exosomes, nano-sized vesicles, mediate cancer cell communication, impacting drug resistance and immune responses. These vesicles show promise for developing novel cancer immunotherapies by activating immune cells.

Area of Science:

  • Cell biology
  • Immunology
  • Nanotechnology

Background:

  • Exosomes are nano-sized vesicles involved in intercellular communication.
  • Exosomes influence cancer progression, including matrix remodeling, drug resistance, and immune modulation.
  • Their inherent properties suggest potential for cancer immunotherapy.

Purpose of the Study:

  • To review recent advances in exosome technology for cancer immunotherapy.
  • To highlight the potential of exosomes in activating immune responses against cancer.

Main Methods:

  • Review of state-of-the-art technologies and protocols for exosome utilization.
  • Analysis of exosome-mediated cell-to-cell communication in cancer.

Main Results:

  • Exosomes play a significant role in various cancer hallmarks.
  • Exosomes possess immunomodulatory potential for activating innate and adaptive immunity.
  • Exosome-based strategies are emerging for effective anticancer immunosurveillance.

Conclusions:

  • Exosomes represent a promising platform for innovative cancer immunotherapy.
  • Harnessing exosome functionalities can lead to novel approaches for cancer treatment.
Keywords:
CAR-T cellsExosomescancer therapydendritic cell–derived exosomesimmunotherapytumor-derived exosomes

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