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Sexual Dysfunction in Early-Onset Parkinson's Disease: A Cross-Sectional, Multicenter Study.

Lydia Vela-Desojo1, Daniele Urso2, Monica Kurtis-Urra3

  • 1Hospital Fundación Alcorcón, Alcorcón, Madrid, Spain.

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|September 14, 2020
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Summary

Sexual dysfunction is common in early-onset Parkinson's disease (PD), affecting 70.2% of patients compared to controls. This study highlights the prevalence of sexual dysfunction and dissatisfaction in EOPD patients, linked to gender and urinary issues.

Keywords:
EOPDParkinson’s diseaseSexual dysfunctionnon-motor symptomssexual satisfaction

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Area of Science:

  • Neurology
  • Urology
  • Sexual Medicine

Background:

  • Sexual dysfunction (SD) is an understudied non-motor symptom in Parkinson's disease (PD).
  • Early-onset Parkinson's disease (EOPD) presents unique challenges, including potential impacts on sexual health.
  • Understanding SD in EOPD is crucial for comprehensive patient care.

Purpose of the Study:

  • To assess sexual function in a cohort of patients with early-onset PD (EOPD).
  • To compare sexual function in EOPD patients with a group of healthy controls.
  • To identify factors associated with sexual dysfunction and dissatisfaction in EOPD.

Main Methods:

  • Cross-sectional, multicenter study design.
  • Utilized gender-specific questionnaires: The Brief Male Sexual Function Inventory (BSFI-M) and the Female Sexual Function Index (FSFI).
  • Compared scores between 105 EOPD patients and 90 healthy controls, analyzing demographic and clinical variables.

Main Results:

  • Sexual dysfunction (SD) was prevalent in 70.2% of EOPD patients versus 52.5% of controls.
  • EOPD men reported lower scores in drive, erections, ejaculation, and satisfaction compared to controls.
  • EOPD women showed lower FSFI scores, particularly in lubrication and pain domains; only 35.2% reported sexual satisfaction compared to 81.2% of controls.
  • Multivariate analysis indicated gender, depression, and urinary dysfunction were associated with SD; gender, UPDRS, and urinary dysfunction were linked to sexual satisfaction.

Conclusions:

  • Sexual dysfunction and dissatisfaction are more prevalent in EOPD patients than in the general population.
  • Gender and urinary dysfunction are significant factors associated with SD and sexual dissatisfaction in EOPD.
  • Further research and targeted interventions are needed to address sexual health concerns in EOPD.