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Updated: Dec 9, 2025
05:44
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
641
New classification criteria for systemic lupus erythematosus
Martin Aringer1, Michelle Petri2
1Division of Rheumatology, Department of Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany.
Current Opinion in Rheumatology
|September 14, 2020
Summary
The new European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) SLE classification criteria enhance specificity compared to SLICC criteria. Both EULAR/ACR and SLICC criteria recognize key clinical and immunological factors in systemic lupus erythematosus.
Area of Science:
- Rheumatology
- Immunology
- Systemic Lupus Erythematosus (SLE) classification
Background:
- Existing classification criteria for SLE include ACR and SLICC.
- Recent advancements led to the development of new EULAR/ACR classification criteria.
Purpose of the Study:
- To compare the new EULAR/ACR SLE classification criteria with SLICC and earlier ACR criteria.
- Focus on the key concepts and performance of each criterion set.
Main Methods:
- Comparative analysis of the structural and conceptual differences between EULAR/ACR, SLICC, and ACR criteria.
- Evaluation of statistical performance, including sensitivity and specificity.
Main Results:
- EULAR/ACR criteria incorporate antinuclear antibodies (ANA) as obligatory, use weighted criteria, and group items into domains.
- SLICC criteria increased sensitivity but reduced specificity, while EULAR/ACR criteria improved specificity.
- Both EULAR/ACR and SLICC criteria acknowledge the significance of immunological and clinical findings, lupus nephritis, and most clinical items.
Conclusions:
- Despite structural and performance differences, EULAR/ACR and SLICC criteria show agreement on core SLE classification elements.
- The EULAR/ACR criteria offer excellent performance with enhanced specificity for SLE classification.
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