Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

242
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
242
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

509
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
509
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

174
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
174
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

184
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
184
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

308
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
308
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

220
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
220

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized, noninferiority clinical trial of Single-Shot Intrathecal Morphine versus Continuous Wound Infiltration for postoperative pain control after open pancreatoduodenectomy.

The British journal of surgery·2026
Same author

Beyond numeric scales: validity of the EQ-5D-5L pain/discomfort dimension in postoperative pain assessment after minimally invasive colorectal cancer surgery.

The Korean journal of pain·2026
Same author

Response to "Unequal Local Anesthetic Dosing and Surgical Heterogeneity: Considerations for Interpreting the ESPB-TEA Non-Inferiority Trial" [Response to Letter].

Journal of pain research·2026
Same author

Early postoperative pain and its association with complications after minimally invasive colorectal cancer surgery: a retrospective cohort study of a multicenter database.

Korean journal of anesthesiology·2026
Same author

The Effect of Aza-Glycine Substitution on the Internalization of Dabcyl-Containing Short Oligoarginine.

Biomedicines·2026
Same author

Beyond opioid dosage: temporal dynamics of intravenous patient-controlled analgesia use captured by electronic device logs-a post hoc analysis of three randomized controlled trials.

The Korean journal of pain·2026

Related Experiment Video

Updated: Dec 9, 2025

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.1K

Hydroxyethyl Starch 6% 130/0.4 in a Balanced Electrolyte Solution and Renal Function After Nephrectomy.

Ho-Jin Lee1, Yongsuk Kwon, Jinyoung Bae

  • 1From the Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Anesthesia and Analgesia
|September 14, 2020
PubMed
Summary

Intraoperative hydroxyethyl starch (HES) administration did not significantly impact kidney function or survival after nephrectomy. However, the wide confidence intervals suggest further research is needed to confirm safety.

More Related Videos

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.8K
Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.4K

Related Experiment Videos

Last Updated: Dec 9, 2025

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.1K
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.8K
Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.4K

Area of Science:

  • Nephrology
  • Surgical Outcomes
  • Pharmacology

Background:

  • Previous studies linked hydroxyethyl starch (HES) to nephrotoxicity.
  • Long-term renal effects of HES post-nephrectomy remain under-investigated.

Purpose of the Study:

  • To evaluate the association between intraoperative HES administration and short- and long-term renal function after nephrectomy.
  • To assess the impact of HES on new-onset chronic kidney disease (CKD) stage 3a or higher and all-cause mortality up to 60 months post-surgery.

Main Methods:

  • Retrospective review of 1106 patients undergoing partial or radical nephrectomy.
  • Comparison between patients receiving (HES group) and not receiving (non-HES group) 6% HES 130/0.4 intraoperatively.
  • Propensity score matching, ordinal logistic regression, and Cox proportional hazards regression analyses were employed.

Main Results:

  • No significant difference in renal survival between HES and non-HES groups after matching.
  • Similar incidence of acute kidney injury (AKI) and CKD upstaging at 1 year post-surgery between groups.
  • Intraoperative HES was not associated with postoperative renal outcomes (AKI, CKD, or mortality).

Conclusions:

  • Intraoperative 6% HES 130/0.4 administration showed no significant association with short- or long-term renal function or survival up to 5 years post-nephrectomy.
  • Wide confidence intervals preclude a definitive conclusion on safety.
  • Further assessment of HES safety in this patient population is warranted.