Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of anovulation.

G Schaison1

  • 1Service d'Endocrinologie et des Maladies de la Reproduction, Hopital Bicêtre, Kremlin-Bicêtre, France.

Human Reproduction (Oxford, England)
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute Myeloid Leukemia in Children Less Than Two Years Old: Clinical, Cytologic and Cytogenetic Correlations Comparison with other age categories. A clinical survey of 39 cases.

Leukemia & lymphoma·2016
Same author

[Pilot study and preliminary validation of the French version of a quality-of-life questionnaire specific for subjects with growth hormone deficiency].

Annales d'endocrinologie·2003
Same author

Post menopausal ovarian steroidogenesis.

Annales d'endocrinologie·2003
Same author

Day-care, early common infections and childhood acute leukaemia: a multicentre French case-control study.

British journal of cancer·2002
Same author

Family cancer history and risk of childhood acute leukemia (France).

Cancer causes & control : CCC·2002
Same author

The postmenopausal ovary is not a major androgen-producing gland.

The Journal of clinical endocrinology and metabolism·2001
Same journal

Characterizing endometriosis and adenomyosis symptom clusters and their impact on quality of life in the All of Us Research Program.

Human reproduction (Oxford, England)·2026
Same journal

A new regulatory framework: impact of the SoHO Regulation for medically assisted reproduction.

Human reproduction (Oxford, England)·2026
Same journal

Subfertility in relation to gestational weight gain and gestational diabetes: the Norwegian Mother, Father and Child Cohort Study.

Human reproduction (Oxford, England)·2026
Same journal

Pathogenic variants in ACTRT3 lead to male infertility characterized by fertilization defects.

Human reproduction (Oxford, England)·2026
Same journal

A large retrospective study on 1PN embryo transfer supports the need for updated harmonized best practice guidelines.

Human reproduction (Oxford, England)·2026
Same journal

Explainability of artificial intelligence (AI) tools in assisted reproductive technologies (ARTs): promise, clinical reality, and conceptual limits.

Human reproduction (Oxford, England)·2026
See all related articles

Anovulatory disorders, a common reproductive issue, stem from various conditions affecting the hypothalamus and ovaries. Understanding their pathophysiology is key to diagnosis and treatment.

Area of Science:

  • Reproductive Endocrinology
  • Neuroendocrinology

Background:

  • Anovulatory disorders are common in women, occurring physiologically during specific life stages and pathologically as symptoms of underlying diseases.
  • These disorders can arise from hypothalamic dysfunction, pituitary issues, or primary ovarian insufficiency, highlighting complex regulatory pathways.

Purpose of the Study:

  • To explore the pathophysiology of anovulatory disorders, focusing on functional hypothalamic disorders and the role of endogenous opioids.
  • To discuss the antigonadotrophic effects of hyperprolactinemia and the mechanisms of prolactin's inhibition on GnRH release.
  • To examine the pathophysiology of polycystic ovarian disease (PCOD), including the contributions of hypothalamic disturbances and gonadal steroid feedback.

Main Methods:

  • Review of literature on the pathophysiology of anovulatory disorders.

Related Experiment Videos

  • Discussion of the role of endogenous opioids in gonadotropin regulation.
  • Analysis of the hypothalamic effects of hyperprolactinemia and prolactin's impact on GnRH.
  • Examination of the interplay between hypothalamic dysfunction and gonadal steroid feedback in PCOD.

    • Main Results:

    • Functional hypothalamic disorders involve impaired physiological release of gonadotropin-releasing hormone (GnRH).
    • Hyperprolactinemia exerts an antigonadotrophic effect at the hypothalamic level, though the precise mechanism of prolactin's inhibition on GnRH requires further elucidation.
    • The pathophysiology of PCOD is complex, involving contributions from both hypothalamic disturbances and abnormal gonadal steroid feedback.

    Conclusions:

    • Anovulatory disorders have diverse etiologies, necessitating a thorough understanding of their underlying pathophysiology.
    • Further research is needed to fully elucidate the mechanisms by which prolactin inhibits GnRH and the specific roles of hypothalamic factors and gonadal steroids in PCOD.