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Increased red blood cell distribution width might predict left ventricular hypertrophy in patients with atrial

Hui-Ming Yao1, Xiao-Lei Wang2, Xiong Peng1

  • 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University.

Medicine
|September 14, 2020
PubMed

Insights

Red blood cell distribution width is linked to left ventricular hypertrophy in atrial fibrillation patients. Higher red blood cell distribution width indicates increased risk, while lower low-density lipoprotein and ejection fraction show protective associations.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Research

Background:

  • Left ventricular hypertrophy (LVH) is an independent risk factor for stroke and death in patients with atrial fibrillation (AF).
  • Identifying risk factors for LVH in AF patients is crucial for risk stratification and management.
  • Previous studies have not fully elucidated the specific predictors of LVH in this population.

Purpose of the Study:

  • To investigate the potential risk factors associated with left ventricular hypertrophy in patients diagnosed with atrial fibrillation.
  • To determine the predictive value of identified risk factors for LVH in AF patients.

Main Methods:

  • Retrospective analysis of clinical data from 87 consecutive patients with atrial fibrillation.
  • Multivariate logistic regression to identify independent risk factors for LVH.
  • Receiver operating characteristic (ROC) curve analysis to determine cut-off values, sensitivity, and specificity of predictors.

Main Results:

  • Red blood cell distribution width (RDW) was identified as an independent risk factor for LVH (OR 4.89, P<0.05).
  • Low-density lipoprotein (LDL) concentration (OR 0.37, P<0.05) and left ventricular ejection fraction (LVEF) (OR 0.88, P<0.05) were inversely associated with LVH.
  • ROC analysis showed an area under the curve of 0.80 for RDW, with a cut-off of 13.05, sensitivity of 72.1%, and specificity of 76.9% in predicting LVH.

Conclusions:

  • Red blood cell distribution width is significantly associated with left ventricular hypertrophy in patients with atrial fibrillation.
  • RDW may serve as a valuable biomarker for predicting LVH in AF patients.
  • Further prospective studies are warranted to confirm these findings and explore therapeutic implications.

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