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Related Experiment Video

Updated: Dec 9, 2025

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

Imaging Butyrylcholinesterase in Multiple Sclerosis.

M W D Thorne^1,2, M K Cash¹, G A Reid¹

¹Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada.

Molecular Imaging and Biology

|September 14, 2020

Summary

Butyrylcholinesterase (BChE) imaging agents show potential for detecting multiple sclerosis (MS) lesions and subtle white matter changes. This study found BChE activity correlates with microglial activation in MS white matter lesions.

Keywords:

Autoradiography Butyrylcholinesterase Molecular imaging Multiple sclerosis

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Last Updated: Dec 9, 2025

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

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Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

Published on: March 1, 2017

Area of Science:

Neuroscience
Radiochemistry
Pathology

Background:

Butyrylcholinesterase (BChE) imaging agents show promise in neurodegenerative disorders.
BChE activity is present in white matter and linked to activated microglia in multiple sclerosis (MS) lesions.

Purpose of the Study:

Characterize cholinergic system changes in MS pathology.
Explore BChE radioligands for MS diagnosis and treatment monitoring.

Main Methods:

Identified MS lesions using myelin staining and classified microglial activation.
Performed cholinesterase histochemistry and in vitro autoradiography with ¹²³I-PIP.

Main Results:

BChE activity positively correlated with microglial activation in white matter MS lesions.
¹²³I-PIP uptake was absent in demyelinated lesions but present in normal and normal-appearing white matter.

Conclusions:

BChE imaging agents may detect MS lesions and subtle pathology in normal-appearing white matter.
BChE agents could supplement current MS diagnostic and treatment monitoring strategies.