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Aging attenuates the ovarian circadian rhythm
Ziru Jiang1,2, Kexin Zou1,2, Xia Liu1,2
1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, 910 Hengshan Road, Shanghai, 200030, China.
Journal of Assisted Reproduction and Genetics
|September 14, 2020
Summary
Aging disrupts ovarian circadian rhythms, leading to reduced expression of key clock genes and lower anti-Müllerian hormone (AMH) levels in women. This ovarian circadian dysrhythmia contributes to decreased ovarian reserve in older women.
Area of Science:
- Reproductive biology and chronobiology.
Background:
- Aging significantly impacts female reproductive function.
- Circadian rhythms regulate physiological processes, including those in the ovary.
Purpose of the Study:
- To investigate the effect of aging on the ovarian circadian rhythm in humans and mice.
- To explore the relationship between aging, circadian gene expression, and ovarian reserve markers.
Main Methods:
- Analysis of circadian gene expression in human granulosa cells from women of different ages.
- Assessment of ovarian and liver circadian rhythms in young and aged female C57BL/6 mice.
- Correlation of gene expression with age and anti-Müllerian hormone (AMH) levels.
Main Results:
- Aging was associated with decreased expression of circadian clock genes in human granulosa cells.
- Older women (≥40 years) exhibited lower AMH levels, correlated with circadian gene expression.
- Ovarian circadian rhythmicity was significantly altered in aged mice, while liver rhythm remained largely consistent.
Conclusions:
- Aging-induced ovarian circadian dysrhythmia is a contributing factor to reduced ovarian reserve in older women.
- Circadian clock gene expression is linked to ovarian function and reserve during aging.
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