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Cohort Identification for Translational Bioinformatics Studies.

Tiffany A Lin1,2, Zeynep Eroglu2,3, Rodrigo Carvajal4

  • 1Collaborative Data Services Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

Methods in Molecular Biology (Clifton, N.J.)
|September 14, 2020
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Summary
This summary is machine-generated.

Identifying patient cohorts for translational research is crucial for therapeutic development. This study details a standard process using health information systems and database querying for efficient cohort identification in oncology.

Keywords:
BioinformaticsCohort identificationInformaticsResource paperTranslational science

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Area of Science:

  • Oncology
  • Translational Research
  • Bioinformatics

Background:

  • Translational studies require precise patient cohort identification for therapeutic development.
  • Accessing health information systems presents challenges for selecting biological specimens.
  • Standardized methods are needed for efficient cohort identification in cancer research.

Purpose of the Study:

  • To describe the standard process for cohort identification used by Moffitt Cancer Center's Cutaneous Oncology Program and Collaborative Data Services Core (CDSC).
  • To outline the regulatory and procedural aspects of using health information management systems for patient cohort filtering.

Main Methods:

  • Utilized graphical user interfaces (GUIs) for data visualization and interaction.
  • Employed database querying to efficiently filter patient data.
  • Integrated health information management systems for cohort identification.

Main Results:

  • A standard operating procedure for cohort identification was established.
  • The described methods facilitate the selection of appropriate biological specimens for translational studies.
  • Regulatory and procedural guidelines for utilizing health information systems were outlined.

Conclusions:

  • The described methodology provides a robust framework for cohort identification in translational oncology.
  • Effective utilization of health information systems is key to advancing therapeutic development through precise patient selection.