Related Experiment Video

Updated: Dec 9, 2025

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

10.1K

Mineral bone disease in autosomal dominant polycystic kidney disease

Berenice Gitomer1, Renata Pereira2, Isidro B Salusky2

  • 1Division of Renal Diseases and Hypertension, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA.

Kidney International
|September 14, 2020
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) patients show altered bone metabolism with lower bone formation rates. However, ADPKD does not increase fracture risk in end-stage kidney disease patients.

Area of Science:

  • Nephrology
  • Bone Biology
  • Metabolic Diseases

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder often leading to chronic kidney disease.
  • Bone health in early-stage ADPKD patients remains understudied.
  • Previous research in animal models indicates Pkd1 disruption affects bone density.

Purpose of the Study:

  • To investigate the bone phenotype in adult ADPKD patients with early-stage chronic kidney disease.
  • To analyze bone turnover markers and bone biology in ADPKD patients.
  • To assess fracture risk in ADPKD patients with end-stage kidney disease.

Main Methods:

  • Biochemical markers of mineral metabolism were measured in 944 patients.
  • Bone biopsies from 20 ADPKD patients and 17 healthy controls underwent histomorphometry and immunohistochemistry.
  • Fracture risk was analyzed in end-stage kidney disease patients initiating hemodialysis.

Main Results:

  • ADPKD patients had higher intact fibroblast growth factor 23 and lower total alkaline phosphatase.
  • Bone biopsies revealed significantly lower osteoid volume/bone volume and bone formation rate in ADPKD patients compared to controls.
  • End-stage kidney disease due to ADPKD was not associated with increased fracture risk compared to diabetes or other kidney disease etiologies.

Conclusions:

  • Individuals with ADPKD exhibit distinct bone metabolic profiles, including elevated FGF23 and reduced bone formation.
  • Despite altered bone biology, ADPKD does not appear to elevate fracture risk in end-stage kidney disease.
  • Further research may elucidate the long-term skeletal implications of ADPKD.

Keywords:
ADPKDbonemineral metabolism

More Related Videos

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

11.8K
Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease12:47

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

Published on: February 3, 2012

39.1K

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
403
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
398
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
5.6K
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.2K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
243
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
601