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Published on: July 31, 2017
Zinc as a plausible epigenetic modulator of glioblastoma multiforme
Vignesh Balaji E1, Nitesh Kumar1, Sairaj Satarker1
1Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
Abstract:
Glioblastoma Multiforme (GBM) is an aggressive brain tumor (WHO grade 4 astrocytoma) with unknown causes and is associated with a reduced life expectancy. The available treatment options namely radiotherapy, surgery and chemotherapy have failed to improve life expectancy. Out of the various therapeutic approaches, epigenetic therapy is one of the most studied. Epigenetic therapy is involved in the effective treatment of GBM by inhibiting DNA methyltransferase, histone deacetylation and non-coding RNA. It also promotes the expression of the tumor suppressor gene and is involved in the suppression of the oncogene. Various targets are being studied to implement proper epigenetic regulation to control GBM effectively. Zinc is one of the micronutrients which is considered to maintain epigenetic regulation by promoting the proper DNA folding, protecting genetic material from the oxidative damage and controlling the enzyme activation involved in the epigenetic regulation. Here, we are discussing the importance of zinc in regulating the epigenetic modifications and assessing its role in glioblastoma research. The discussion also highlights the importance of artificial intelligence using epigenetics for envisaging the glioma progression, diagnosis and its management.
Insights
Zinc plays a crucial role in epigenetic regulation for glioblastoma (GBM) treatment. Understanding zinc
Area of Science:
- Neuro-oncology
- Epigenetics
- Nutritional Science
Background:
- Glioblastoma Multiforme (GBM) is an aggressive WHO grade 4 astrocytoma with poor prognosis.
- Current treatments like radiotherapy, surgery, and chemotherapy offer limited survival benefits.
- Epigenetic therapy, targeting DNA methylation and histone deacetylation, shows promise for GBM treatment.
Purpose of the Study:
- To discuss the significance of zinc in epigenetic regulation.
- To assess the role of zinc in glioblastoma research.
- To highlight the integration of artificial intelligence with epigenetics for glioma management.
Main Methods:
- Review of current literature on epigenetic modifications in GBM.
- Analysis of zinc's role in DNA folding, oxidative damage protection, and enzyme activation.
- Exploration of AI applications in epigenetic-based glioma research.
Main Results:
- Zinc is essential for maintaining epigenetic regulation through various mechanisms.
- Zinc's involvement in epigenetic processes suggests a potential therapeutic role in GBM.
- AI can enhance the understanding and management of glioma progression using epigenetic data.
Conclusions:
- Zinc is a critical micronutrient for epigenetic stability and may offer therapeutic benefits for GBM.
- Further research into zinc's epigenetic functions is warranted for novel GBM treatment strategies.
- Integrating AI with epigenetics holds significant potential for advancing glioma diagnosis and treatment.
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