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A Core Outcome Set and minimum reporting set for intervention studies in growth restriction in the NEwbOrN: the

Stefanie E Damhuis1, Frank H Bloomfield2, Asma Khalil3

  • 1Department of Obstetrics and Gynaecology, University Medical Center of Groningen, University of Groningen, Groningen, The Netherlands. s.e.damhuis@umcg.nl.

Pediatric Research
|September 14, 2020
PubMed

Insights

This study developed a core outcome set (COS) and minimum reporting set (MRS) to standardize reporting for feeding interventions in growth-restricted newborns. This will improve data synthesis and meta-analyses for better infant outcomes.

Area of Science:

  • Neonatology
  • Pediatric Research
  • Clinical Trial Methodology

Background:

  • Standardization of outcomes is lacking in feeding intervention trials for growth-restricted newborns.
  • This limits the ability to pool data and analyze intervention effects effectively.
  • A core outcome set (COS) and minimum reporting set (MRS) are needed for this field.

Purpose of the Study:

  • To develop a consensus-based core outcome set (COS).
  • To develop a consensus-based minimum reporting set (MRS).
  • For studies involving feeding interventions in growth-restricted newborns.

Main Methods:

  • Scoping search to identify relevant outcomes and baseline characteristics.
  • Three rounds of online Delphi surveys with lay and professional stakeholders.
  • Face-to-face consensus meeting to finalize the COS and MRS.

Main Results:

  • Consensus was reached on 19 outcomes and 17 baseline characteristics.
  • 89% of initial experts completed all three survey rounds.
  • The developed sets represent an international consensus.

Conclusions:

  • A COS and MRS for feeding interventions in growth-restricted newborns have been established.
  • These sets will standardize reporting and improve data synthesis.
  • Facilitates meta-analysis of multiple studies to optimize interventions.
Abstract

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