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Single gold nanoclusters: Formation and sensing application for isonicotinic acid hydrazide detection
Yuanyuan Qian1, Haoran Tang1, Yongxin Li1
1Anhui Key Laboratory of Chemo/Biosensing, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, PR China.
Talanta
|September 15, 2020
Summary
Single gold nanoclusters on platinum nanoelectrodes enable sensitive detection of isonicotinic acid hydrazide (INH). This novel sensor platform demonstrates excellent performance for INH analysis in human urine samples.
Area of Science:
- Electrochemistry
- Nanomaterials Science
- Analytical Chemistry
Background:
- Nano-sized electrodes offer advantages like small dimensions and fast response times for sensing.
- Gold nanoclusters (AuNCs) present unique electrochemical properties.
- Platinum nanoelectrodes (PtNEs) are suitable platforms for electrochemical applications.
Purpose of the Study:
- To controllably prepare single gold nanoclusters (AuNCs) on single platinum nanoelectrode (PtNE) surfaces.
- To investigate the electrochemical behavior of isonicotinic acid hydrazide (INH) on AuNCs/PtNE.
- To develop a sensitive and selective sensor for INH detection.
Main Methods:
- Electrodeposition of AuNCs onto PtNEs.
- Voltammetric analysis using square wave voltammetry (SWV).
- Chronoamperometry for electrochemical measurements.
Main Results:
- Successfully prepared AuNCs on PtNEs with steady-state voltammetric response.
- Demonstrated significant electrochemical response of INH on the AuNCs/PtNE surface.
- Achieved sensitive, reproducible, and selective INH detection.
Conclusions:
- AuNCs/PtNEs serve as an effective platform for INH electrochemical sensing.
- The developed sensor shows potential for INH detection in complex biological matrices like human urine.
