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Pneumonia III: Complications and Assessment01:30

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Related Experiment Video

Updated: Dec 9, 2025

Author Spotlight: Advancing Pathogen Diagnostics with Standardized LAMP
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Diagnostic techniques for COVID-19 and new developments.

Elham Sheikhzadeh1, Shimaa Eissa2, Aziah Ismail1

  • 1Institute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia16150 Kubang Kerian, Kelantan, Malaysia.

Talanta
|September 15, 2020
PubMed
Summary
This summary is machine-generated.

Early diagnosis of COVID-19 is critical due to SARS-CoV-2 rapid spread. This review covers various detection methods, including RT-PCR, immunological assays, and biosensors, for timely identification and control.

Keywords:
BiosensorsCOVID-19.Immunological assays.Molecular methods.SARS-CoV-2.

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Area of Science:

  • Virology
  • Infectious Diseases
  • Diagnostic Technologies

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, presents a significant global health challenge due to its rapid human-to-human transmission and potential for fatal pneumonia.
  • SARS-CoV-2 exhibits a higher transmission rate compared to other coronaviruses like SARS and MERS, with no specific approved treatments or vaccines currently available.
  • Effective containment strategies rely heavily on early and accurate diagnosis to facilitate prompt patient identification and isolation, thereby limiting disease spread.

Purpose of the Study:

  • To review and discuss the diverse range of diagnostic methods for detecting SARS-CoV-2.
  • To highlight recent advancements in immunological assays, amplification techniques, and biosensors for COVID-19 diagnosis.
  • To provide an overview of current and emerging technologies crucial for controlling the spread of SARS-CoV-2 infections.

Main Methods:

  • Review of existing literature on SARS-CoV-2 detection methodologies.
  • Analysis of current diagnostic standards, including Reverse Transcription-Polymerase Chain Reaction (RT-PCR).
  • Exploration of novel and developing diagnostic approaches such as immunological assays, nucleic acid amplification techniques, and biosensor technologies.

Main Results:

  • Reverse Transcription-Polymerase Chain Reaction (RT-PCR) remains the most common method for SARS-CoV-2 detection.
  • Ongoing research is yielding faster and more accurate diagnostic assays beyond RT-PCR.
  • Immunological assays, advanced amplification techniques, and biosensors show promise for improved COVID-19 diagnostics.

Conclusions:

  • Early and precise diagnosis of SARS-CoV-2 is paramount for managing the COVID-19 pandemic.
  • A variety of detection methods are available, with ongoing innovation focusing on speed and accuracy.
  • The development and implementation of diverse diagnostic tools are essential for controlling the global spread of SARS-CoV-2.