Related Experiment Video
Updated: Dec 9, 2025

03:42
Author Spotlight: Validating Cancer Therapy Responses with Desmoplastic Spheroid Models
Published on: September 27, 2024
1.9K
Blocking CTGF-Mediated Tumor-Stroma Interplay in Pancreatic Cancer
Yi-Wen Shen1, Yu-Dong Zhou2, Xin Luan1
1Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Trends in Molecular Medicine
|September 15, 2020
Abstract:
As the major feature of pancreatic ductal adenocarcinoma (PDAC), desmoplastic stroma poses a significant obstacle for treatment. Recent studies revealed that connective tissue growth factor (CTGF) aggravates the fibrotic environment and drives cancer initiation and progression, thus suggesting CTGF as a novel target for PDAC treatment.

