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Updated: Dec 9, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Atypical case of COVID-19 in a critically unwell 5-week old infant
Abirami Namasivayam1, Than Soe2, Jason Palman2
1Paediatrics, Princess Alexandra Hospital NHS Trust, Harlow, UK a.namasivayam@nhs.net.
Insights
Severe COVID-19 infection in infants is an evolving concern. This case highlights atypical presentations and challenges in pediatric airway management for SARS-CoV-2.
Area of Science:
- Pediatrics
- Infectious Diseases
- Critical Care Medicine
Background:
- Early reports suggested children were less affected by SARS-CoV-2 (COVID-19).
- Emerging evidence indicates a potential for systemic inflammatory responses in pediatric cases.
- Understanding COVID-19's impact on the pediatric population is crucial and ongoing.
Observation:
- A 5-week-old male infant presented with severe COVID-19 infection.
- This infant required mechanical ventilation and intensive care, representing the youngest reported case in the UK.
- The infection was acquired through horizontal transmission.
Findings:
- The infant's presentation was atypical for severe COVID-19 in children.
- This case underscores the variability in SARS-CoV-2 presentation among infants.
- Identifying 'at risk' infant populations for COVID-19 is a developing area.
Implications:
- This case offers critical learning points for managing severe COVID-19 in neonates and infants.
- New challenges in pediatric airway management for SARS-CoV-2-infected infants are identified.
- Further research is needed to understand and manage COVID-19's effects on vulnerable infants.
Abstract:
The effect of COVID-19 by SARS-CoV-2 on the paediatric population remains an evolving mystery. Early reports from China stated that children seem to be unharmed by its dangerous effects, yet more recently there has been evidence of a systemic inflammatory response in a small number of children who are affected. We discuss a 5-week-old male infant who presented atypically with severe COVID-19 infection. To our knowledge, he is the youngest reported case in the UK to require mechanical ventilation and intensive care treatment as a direct result of COVID-19 following horizontal transmission. This case has generated several learning points with regard to atypical presentations of COVID-19 and identifying a potential cohort of 'at risk' infants. We also highlight a number of new challenges that have arisen for paediatricians and anaesthetists providing airway management for infants with SARS-CoV-2.
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