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Chloramphenicol: magic bullet or double-edge sword?
1Department of Environmental Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Mutation Research
|July 1, 1988
Abstract:
The genetic and genotoxic potentials of chloramphenicol are reviewed and analyzed. Although this widely used antimicrobial agent appears to cause chromosomal effects in somatic cells, in view of the consistent absence of other genetic effects, these cytogenetic abnormalities are ascribed to non-genotoxic causes. It is pointed out that despite its widespread use in human medicine, chloramphenicol has not been systematically tested for genotoxicity.