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Updated: Dec 9, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis

Qi Zhang1, Cheng Cao1, Wenchen Gong1

  • 1State Key Laboratory of Experimental Hematology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University General Hospital, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.

Theranostics
|September 15, 2020
PubMed
Summary

Epithelial cell transforming factor ECT2 promotes breast cancer growth independently of its guanine nucleotide exchange factor (GEF) activity. It forms a feedback loop with USP7, stabilizing both proteins and sustaining oncogenic MDM2 expression for cancer cell survival.

Keywords:
Breast cancerDeubiquitinaseDeubiquitinationGuanine nucleotide exchange factorsProtein stability

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