Related Experiment Video
Updated: Dec 9, 2025
09:15
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
14.9K
Targeting hypertriglyceridemia to mitigate cardiovascular risk: A review
Peter P Toth1,2, Prediman K Shah3, Norman E Lepor3
1CGH Medical Center, Sterling, IL, USA.
American Journal of Preventive Cardiology
|September 15, 2020
Summary
Elevated triglycerides increase cardiovascular risk. Prescription eicosapentaenoic acid significantly reduced cardiovascular events in high-risk patients, suggesting benefits beyond triglyceride lowering.
Area of Science:
- Cardiology
- Biochemistry
Background:
- The causal link between high triglycerides and cardiovascular disease (CVD) remains debated.
- Hypertriglyceridemia is linked to atherosclerosis and acute cardiovascular events, even with statin therapy.
Purpose of the Study:
- To evaluate the efficacy of prescription eicosapentaenoic acid in reducing cardiovascular events in high-risk patients.
- To investigate the role of triglyceride levels in the observed cardiovascular benefits.
Main Methods:
- The REDUCE-IT trial enrolled high-risk patients with triglyceride levels between 135-499 mg/dL on statin therapy.
- Participants received either 4g/day of icosapent ethyl or a placebo.
Main Results:
- Icosapent ethyl significantly reduced cardiovascular events by 25% compared to placebo (HR 0.75; 95% CI 0.68-0.83).
- The cardiovascular benefit was consistent across various baseline and on-treatment triglyceride levels.
Conclusions:
- Prescription eicosapentaenoic acid is effective in reducing cardiovascular events in high-risk patients.
- The benefits of icosapent ethyl may extend beyond its triglyceride-lowering effects.
Related Concept Videos
01:26Atherosclerosis III: Management
225
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
225
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.2K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.2K
01:26Coronary Artery Disease IV: Preventive Measures
507
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
507
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
475
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
475
01:28Hypertension IV: Drug Therapy and Lifestyle Modifications
404
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
404
01:26Angina IV: Management
159
IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
159