Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Lethal Progressive Neuroinflammation Disguised as MOGAD Revealing a Final Diagnosis of Griscelli Syndrome.

Annals of clinical and translational neurology·2026

Same author

Understanding the Promise and Challenges of Tumor-Agnostic Therapy: Could One Size Really Fit All?

Cancers·2026

Same author

Compound Heterozygous <i>COA7</i> Variants Presenting With Childhood-Onset Axonal Neuropathy in 2 Siblings.

Neurology. Genetics·2026

Same author

The phenotypic spectrum and genetic determinants of severe spinal muscular atrophy in individuals with a single <i>SMN2</i> copy: an international retrospective observational study.

EClinicalMedicine·2026

Same author

eSIG-Net: an interaction language model that decodes the protein code of single mutations.

Nature methods·2026

Same author

Safety and Tolerability of Givinostat: Evidence From Real-World and Clinical Practice.

Annals of clinical and translational neurology·2026

Search research articles

Related Experiment Video

Updated: Dec 9, 2025

Quantitative Immunofluorescence to Measure Global Localized Translation

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

Current methods in translational cancer research.

Michael W Lee^1,2,3, Mihailo Miljanic^2,3, Todd Triplett^2,3

¹Department of Medical Education, Dell Medical School, University of Texas at Austin, Austin, TX, USA.

Cancer Metastasis Reviews

|September 15, 2020

Summary

This summary is machine-generated.

New pre-clinical screening tools accelerate drug development. This review evaluates cell culture, organoids, mouse models, and computational approaches to guide researchers in selecting optimal translational research tools for predicting therapeutic efficacy and safety.

Keywords:

Cancer GEMMs PDX Translational research Xenograft tumor immunology

More Related Videos

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Published on: June 23, 2023

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Related Experiment Videos

Last Updated: Dec 9, 2025

Quantitative Immunofluorescence to Measure Global Localized Translation

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Published on: June 23, 2023

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Area of Science:

Pharmacology
Translational Research
Drug Development

Background:

Advancements in pre-clinical screening tools offer improved prediction of therapeutic agent clinical effects and adverse events.
The rapid emergence of these models necessitates careful evaluation of their individual merits for rational drug development.
Translational research tools are crucial for bridging the gap between laboratory findings and clinical outcomes.

Purpose of the Study:

To assess the predictive utility of established and emerging pre-clinical screening methods.
To evaluate the suitability of these models for predicting treatment response and drug properties (pharmacodynamics and pharmacokinetics).
To debate the translational limitations and benefits of current pre-clinical models.

Main Methods:

Review of current literature on cell culture, organoids, in vivo mouse models, and in silico computational approaches.
Analysis of predictive capabilities for treatment response and drug properties.
Discussion of translational aspects, including limitations and benefits.

Main Results:

Established and emerging pre-clinical models show varying degrees of predictive utility for drug development.
Cell culture, organoids, mouse models, and in silico methods each offer unique advantages and limitations.
Gaps in current literature and unmet needs in pre-clinical screening are identified.

Conclusions:

Careful evaluation of pre-clinical tools is essential for informed selection in drug development.
Innovations such as co-clinical trials represent future directions for refining translational research.
Optimizing pre-clinical screening platforms will accelerate the development of safe and effective therapeutics.