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Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

Liquid biopsy technologies for hematological diseases.

Yatian Fu¹, Yiyuan Zhang¹, Bee Luan Khoo¹

¹Department of Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong, China.

Medicinal Research Reviews

|September 15, 2020

Summary

Liquid biopsies offer less invasive disease diagnosis using circulating biomarkers like cell-free DNA (cfDNA) and extracellular vesicles (EV). These advancements, including microfluidics and AI, promise improved diagnostics and precision disease management.

Keywords:

cardiovascular diseases disease monitoring liquid biopsy multiomics patient stratification

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Area of Science:

Biomarker Discovery
Translational Medicine
Diagnostic Technologies

Background:

The discovery of circulating tumor cells has paved the way for less invasive cancer diagnosis through blood-based biomarkers.
Liquid biopsy markers, including exfoliated cells, cfDNA, and EVs, offer a more convenient alternative to traditional biopsies.
Technological advancements enable the characterization of various diseases beyond cancer using these circulating biomarkers.

Purpose of the Study:

To review key cell-based, gene-based, and protein-based liquid biopsy markers (cfDNA, EV) for disease detection.
To discuss research progress in applying liquid biopsy biomarkers across different diseases.
To explore the role of microfluidics and AI in advancing point-of-care liquid biopsy applications.

Main Methods:

Review of existing literature on liquid biopsy technologies and applications.
Highlighting key technologies adopted for hematological diseases.
Introducing recent technological developments for cardiovascular disease, leukemia, and coronavirus disease detection.

Main Results:

Established technologies for hematological disease detection using liquid biopsies.
Emerging technologies for specific detection of cardiovascular, leukemia, and coronavirus diseases.
Identification of microfluidic technology and AI as crucial for point-of-care diagnostics.

Conclusions:

Liquid biopsy markers show significant potential for influencing disease management and treatment.
Noninvasive diagnostic capabilities of these technologies can advance precision disease management.
Integration of microfluidics and AI can enhance the development of point-of-care liquid biopsy applications.