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Updated: Dec 9, 2025
Fabrication of Polymer Microspheres for Optical Resonator and Laser Applications
Published on: June 2, 2017
Process parameters of microsphere preparation based on propylene carbonate emulsion-precursors
Daris Grizić1, Alf Lamprecht1,2
1Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Str. 3, Bonn, Germany.
Aim:
This study aimed for a detailed understanding of the impact of different process parameters involved during celecoxib-loaded microsphere preparation based on propylene carbonate emulsion-precursors.
Methods:
Microspheres were prepared by a modified emulsification-solvent extraction method. Performed investigations included polymer solubility and viscosity, microsphere size, morphology and stability, propylene carbonate content as well as celecoxib solid state, content and release.
Results:
Rough-walled round microspheres with sizes between 21 µm and 122 µm and an internal sponge-like structure filled with residual propylene carbonate (content between 1.9 ± 0.1% and 6.7 ± 0.5% w/w) were obtained. Encapsulation efficiencies varied between 28.3 ± 0.1% and 66.8 ± 1.0%. The release rates were affected by the polymer concentration, the emulsion phase ratio and the residual propylene carbonate content (t50% varied between 2.2 hours and 23.4 hours).
Conclusions:
This study identified the most relevant process parameters for this new preparation method for the model drug celecoxib.
