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Related Experiment Video

Updated: Dec 9, 2025

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Active metronomic vinorelbine schedules decrease plasma interleukin-2 levels in mice with Lewis lung carcinoma.

Paola Orlandi1, Marta Banchi1, Greta Alì2

  • 1Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Pisa, Pisa, Italy.

Journal of Chemotherapy (Florence, Italy)
|September 15, 2020
PubMed
Summary

Metronomic vinorelbine (mVNR) demonstrated significant antitumor effects in a lung cancer model. This treatment also reduced interleukin-2 (IL-2) levels and microvessel density, suggesting multiple anti-cancer mechanisms.

Keywords:
Lewis Lung carcinomainterleukine-2interleukine-8metronomic chemotherapymicevinorelbine

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Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Lewis Lung (LL) carcinoma is a common cancer model.
  • Metronomic chemotherapy offers an alternative dosing strategy.
  • Understanding the immunomodulatory effects of chemotherapy is crucial.

Purpose of the Study:

  • To investigate the antitumor efficacy of metronomic vinorelbine (mVNR) in a Lewis Lung cancer model.
  • To evaluate the impact of mVNR on plasma levels of interleukin-2 (IL-2) and interleukin-8 (IL-8).
  • To assess changes in tumor microvessel density following mVNR treatment.

Main Methods:

  • In vitro antiproliferative assays on LL/2 cells.
  • In vivo studies in immunocompetent C57BL/6 mice bearing Lewis Lung tumors.
  • Dose-dependent administration of mVNR (4-5 mg/Kg, 3 times/week).
  • Quantification of plasma IL-2 and IL-8 levels via ELISA.
  • Assessment of tumor microvessel density using immunohistochemistry.

Main Results:

  • mVNR exhibited a concentration-dependent antiproliferative effect on LL/2 cells in vitro.
  • Significant antitumor activity was observed in vivo at mVNR doses of 4 and 5 mg/Kg.
  • A dose-dependent decrease in plasma IL-2 concentrations was noted, while IL-8 levels remained unaffected.
  • A significant reduction in tumor microvessel density was found at effective mVNR doses.

Conclusions:

  • mVNR demonstrates significant antitumor activity in an immunocompetent Lewis Lung carcinoma model.
  • The efficacy of mVNR may involve the modulation of IL-2 levels and a decrease in tumor angiogenesis.
  • These findings suggest multifaceted mechanisms of action for mVNR in lung cancer treatment.