Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

3.3K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The critical role of hydrogels as an advanced polymeric scaffold in biomedicine: recent progress and challenges.

RSC advances·2026
Same author

<i>In situ</i> meat spoilage monitoring <i>via</i> label-free recognition of ethylenediamine using a flexible paper-based electrochemical sensor.

RSC advances·2026
Same author

Potential screening of oral squamous cell carcinoma using microRNA geno-assay by electrochemical sensing: a new platform in biosensor technology.

RSC advances·2026
Same author

Micro-array based on parafilm towards the opto-analysis of Cu(ii), Cr(vi), and Ni(ii) ions in fish samples by specific indicators: a state-of-the-art approach.

RSC advances·2026
Same author

Developing point-of-need (PON) cancer biosensors using microfluidic paper-based analytical devices: recent advances.

RSC advances·2025
Same author

A Miniaturized Optical Bioassay Towards Early-Stage Diagnosis of Cancer Using Immunosensing of Biomarkers (CA 15.3, PSA and CEA) by Toluidine Blue-Decorated Poly(Methyl Methacrylate): Proof of Concept.

Analytical science advances·2025

Related Experiment Video

Updated: Dec 9, 2025

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

7.7K

Biomedical analysis of exosomes using biosensing methods: recent progress.

Houman Kholafazad Kordasht1,2,3, Mohammad Hasanzadeh4,5

  • 1Department of Food Hygiene and Aquatic, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

Analytical Methods : Advancing Methods and Applications
|September 15, 2020
PubMed
Summary

Exosomes, tiny vesicles crucial for cell communication, show promise as cancer biomarkers. Developing sensitive biosensors for exosome detection is key for early cancer diagnosis and treatment.

More Related Videos

An Innovative Method for Exosome Quantification and Size Measurement
11:38

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

31.3K
Rapid Fluorescence-based Characterization of Single Extracellular Vesicles in Human Blood with Nanoparticle-tracking Analysis
09:16

Rapid Fluorescence-based Characterization of Single Extracellular Vesicles in Human Blood with Nanoparticle-tracking Analysis

Published on: January 7, 2019

10.2K

Related Experiment Videos

Last Updated: Dec 9, 2025

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

7.7K
An Innovative Method for Exosome Quantification and Size Measurement
11:38

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

31.3K
Rapid Fluorescence-based Characterization of Single Extracellular Vesicles in Human Blood with Nanoparticle-tracking Analysis
09:16

Rapid Fluorescence-based Characterization of Single Extracellular Vesicles in Human Blood with Nanoparticle-tracking Analysis

Published on: January 7, 2019

10.2K

Area of Science:

  • Biotechnology
  • Nanomedicine
  • Cancer Research

Background:

  • Exosomes are extracellular vesicles involved in intercellular communication, carrying diverse biomolecules.
  • Exosomes function as potential cancer biomarkers due to their unique cargo, aiding in early cancer detection.
  • Current exosome detection methods face challenges including extensive purification, high false-positive rates, and labeling difficulties.

Purpose of the Study:

  • To review major biosensor types for exosome detection.
  • To discuss the role of nanomaterials in exosome biomedical analysis.
  • To highlight challenges and future directions in developing novel exosome biosensors.

Main Methods:

  • Review of electrochemical, optical, and electrochemiluminescence biosensors.
  • Discussion of exosome detection from various cancer cell lines (breast, ovarian, pancreatic, lung, cervical).
  • Exploration of nanomaterial applications in exosome analysis.

Main Results:

  • Biosensors offer a pathway for detecting cancer-specific exosomes.
  • Nanomaterials enhance the sensitivity and specificity of exosome detection.
  • Most current biosensors target common exosome markers like CD9 and CD63.

Conclusions:

  • Sensitive and selective exosome detection is crucial for clinical applications.
  • Development of novel biosensors is needed to overcome current limitations.
  • This review provides insights for advancing exosome detection in clinical settings.