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Published on: January 27, 2023
Acute severe hypertension associated with acute gastroenteritis in children
Jennifer E Fishbein1, Christine B Sethna2, Pamela Singer2
1Department of Pediatrics, Cohen Children's Medical Center, New Hyde Park, New York, USA.
Insights
Acute severe hypertension in children with gastroenteritis is rare but manageable. Prompt evaluation and treatment led to blood pressure normalization and recovery after the illness resolved, with no lasting effects.
Area of Science:
- Pediatrics
- Cardiology
- Nephrology
Background:
- Acute severe hypertension in children is uncommon.
- Hospitalization for blood pressure management in pediatric acute illness is rare.
- Gastroenteritis can present with severe hypertension in children.
Purpose of the Study:
- To describe cases of acute severe hypertension in children with acute gastroenteritis.
- To investigate the clinical course and outcomes of these patients.
- To highlight the importance of blood pressure assessment in acute pediatric illnesses.
Main Methods:
- Retrospective case series of 10 children.
- Inclusion criteria: acute gastroenteritis, severe hypertension requiring hospitalization.
- Exclusion criteria: underlying kidney pathology, secondary causes of hypertension.
Main Results:
- All 10 children presented with acute severe hypertension and gastroenteritis.
- Two children required intensive care unit admission.
- All patients achieved blood pressure normalization and discontinued antihypertensive treatment upon resolution of gastroenteritis.
Conclusions:
- Acute severe hypertension associated with acute gastroenteritis in children is a distinct clinical entity.
- This condition appears to be transient and resolves with gastroenteritis resolution.
- Thorough blood pressure assessment is crucial in children presenting with acute illnesses.
Abstract:
Acute severe hypertension in otherwise healthy children with acute illness requiring hospitalization for BP management is uncommon and warrants immediate evaluation. We describe 10 cases of children presenting with acute gastroenteritis and found to have acute severe hypertension. They required admission to the hospital for antihypertensive treatment, including 2 to the intensive care unit, but all had normalization of BP and were able to stop treatment with resolution of the acute illness. All patients had thorough testing for secondary causes of hypertension and for signs of end-target organ damage, which were unremarkable. To our knowledge, acute severe hypertension in the setting of acute gastroenteritis without underlying kidney pathology and with complete resolution after illness has not been previously described. The mechanism of this association is not clear, although activation of the sympathetic nervous system is suspected. These cases illustrate the importance of thoroughly assessing BP in the acute setting.
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