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Updated: Dec 9, 2025
06:12
Imaging Dpp Release from a Drosophila Wing Disc
Published on: October 30, 2019
6.0K
Dally-like Is Unlike Dally in Assisting Wingless Spread.
1Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstrasse 15, 48149 Münster, Germany.
Developmental Cell
|September 15, 2020
Summary
Lipidated morphogens like Wingless travel long distances to regulate cell development. Cell-surface proteoglycan Dally-like-protein (Dlp) is key to this long-range signaling process.
Area of Science:
- Developmental Biology
- Cell Signaling
- Molecular Biology
Background:
- Lipidated morphogens are crucial for tissue development and repair.
- The mechanism by which insoluble morphogens achieve long-range signaling is not well understood.
Purpose of the Study:
- To elucidate how cell-surface proteoglycan Dally-like-protein (Dlp) facilitates long-range signaling of the lipidated morphogen Wingless.
Main Methods:
- Investigated the interaction between Dally-like-protein (Dlp) and the morphogen Wingless.
- Utilized genetic and biochemical approaches to study morphogen transport.
Main Results:
- Dally-like-protein (Dlp) plays a critical role in the transport of Wingless.
- Demonstrated that Dlp promotes the spread of Wingless within developing tissues.
Conclusions:
- Dally-like-protein (Dlp) is essential for enabling lipidated morphogens to signal over long distances.
- This finding provides insight into developmental processes and tissue repair mechanisms.
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