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Updated: Dec 9, 2025

Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
Published on: July 12, 2013
Transcriptional ups and downs: patterns of gene expression in the life cycle of Toxoplasma gondii
Janak Sharma1, Paula Rodriguez1, Proyasha Roy1
1Department of Biological Sciences, California State University East Bay, Hayward, CA, USA.
Abstract:
Toxoplasma gondii reproduces sexually in felines and asexually in virtually all warm-blooded animals, including humans. This obligate intracellular parasite alternates between biologically distinct developmental stages throughout its complex life cycle. Stage conversion is crucial for T. gondii transmission, persistence, and the maintenance of genetic diversity within the species. Genome-wide comparative transcriptomic studies have contributed invaluable insights into the regulatory gene networks underlying T. gondii development.
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