Diverse roles of phosphatidate phosphatases in insect development and metabolism

The conversion of the glycerophospholipid phosphatidic acid (PA) into diacylglycerol (DAG) is essential for the biosynthesis of membrane phospholipids and storage fats. Importantly, both PA and DAG can also serve signaling functions in the cell. The dephosphorylation of PA that yields DAG can be executed by two different classes of enzymes, Mg²⁺-dependent lipins and Mg²⁺-independent lipid phosphate phosphatases. Here, I will discuss the current status of research directed at understanding the roles of these enzymes in insect development and metabolism. Special emphasis will be given to studies in the model organism Drosophila melanogaster.