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Updated: Dec 9, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

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Recent advances in developing biosensing based platforms for neonatal sepsis.

Sapna Balayan1, Nidhi Chauhan1, Ramesh Chandra2

  • 1Amity Institute of Nanotechnology, Amity University, Noida, 201313, Uttar Pradesh, India.

Biosensors & Bioelectronics
|September 15, 2020
PubMed
Summary
This summary is machine-generated.

Neonatal sepsis, a deadly bloodstream infection, requires rapid diagnosis for effective treatment. Electrochemical biosensors utilizing nanomaterials offer a promising advancement for early detection of sepsis biomarkers.

Keywords:
BiomarkersBiosensorElectrochemical detectionImmunosensorNanotechnologyNeonatal sepsis

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Area of Science:

  • Biomedical Engineering
  • Infectious Disease Research
  • Nanotechnology Applications

Background:

  • Neonatal sepsis is a critical bloodstream infection causing significant mortality in newborns worldwide.
  • Early and accurate diagnosis is crucial for timely intervention and improved patient outcomes.
  • Common causative agents include E. coli, GBS, and S. aureus, necessitating effective detection methods.

Purpose of the Study:

  • To review current diagnostic platforms for neonatal sepsis.
  • To highlight the role of nanomaterial-based electrochemical biosensors in sepsis detection.
  • To discuss advancements and future scope in biosensor development for neonatal sepsis.

Main Methods:

  • Literature review of diagnostic platforms for neonatal sepsis.
  • Analysis of various screening methods including electrochemical, potentiometric, and impedimetric sensors.
  • Focus on the integration of nanomaterials in biosensor design for biomarker detection.

Main Results:

  • Several biomarkers like SAA, CRP, PCT, and LBP are key indicators of neonatal sepsis.
  • Electrochemical biosensors, especially those incorporating nanomaterials, show enhanced sensitivity and specificity.
  • Diverse diagnostic platforms exist, with nanomaterial-enhanced electrochemical sensors emerging as a superior option.

Conclusions:

  • Nanomaterial-based electrochemical biosensors represent a significant advancement in the rapid and accurate detection of neonatal sepsis.
  • Further development of these platforms holds great promise for improving neonatal healthcare and reducing mortality rates.
  • Continued research into novel screening platforms is essential for combating neonatal sepsis effectively.