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Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
Published on: February 23, 2024
A multi-functional picolinohydrazide-based chemosensor for colorimetric detection of iron and dual responsive
Minuk Yang1, Su Chan Lee1, Mingeun Kim2
1Department of Fine Chem., Seoul Nat. Univ. of Sci. and Tech., Seoul 01821, Republic of Korea.
Abstract:
A novel effective chemosensor HPHN, (E)-6-hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene) picolinohydrazide, was synthesized. HPHN sensed Fe3+/2+ with the changes of color from yellow to orange without obvious inhibition from other cations. In addition, HPHN could detect ClO- by both the color change from yellow to colorless and the fluorescence quenching. The binding modes of HPHN with Fe3+/2+ and ClO- were determined to be 1:1 with Job plot and ESI-mass analysis. HPHN displayed low detection limits of 0.29 μM for Fe3+ and 0.77 μM for Fe2+. For ClO-, the detection limit was 6.20 μM by colorimetric method and 3.99 μM by fluorescent one, respectively. Moreover, HPHN can be employed to quantify Fe3+ and ClO- in environmental samples and apply to cell imaging for ClO-.
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