Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.4K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.4K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

41.2K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-associated neuronal micronuclei formation and transfer to microglia.

Frontiers in aging neuroscience·2026
Same author

Roles of Del-1 in effects of hyponatremia on muscle and bone in mice.

Bone·2026
Same author

Inhibition of MAFB and PI3K/AKT Signaling for Hereditary FSGS with Multicentric Carpotarsal Osteolysis.

Journal of the American Society of Nephrology : JASN·2026
Same author

The Nrf2-SLPI axis in aging and its role in the pathophysiology of pulmonary <i>Mycobacterium avium</i> complex disease.

Frontiers in immunology·2026
Same author

0.33<i>g</i> mitigates muscle atrophy while 0.67<i>g</i> preserves muscle function and myofiber type composition in mice during spaceflight.

Science advances·2026
Same author

Chromatin Immunoprecipitation Sequencing and RNA Sequencing from Laser-Microdissected Human Lung Cancer Cells.

Methods in molecular biology (Clifton, N.J.)·2026

Related Experiment Video

Updated: Dec 9, 2025

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

1.7K

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight.

Shin-Ichiro Fujita1,2, Lindsay Rutter2, Quang Ong1,2

  • 1Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan.

Life (Basel, Switzerland)
|September 16, 2020
PubMed
Summary

Spaceflight alters clock gene expression in mice, disrupting circadian rhythms between tissues. Understanding these space biology changes may lead to new health countermeasures for Earth and space.

Keywords:
RNA-seqbioinformaticscircadian rhythmgene expressiongenomicsmicrogravityspace biologyspaceflight

More Related Videos

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

7.8K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.9K

Related Experiment Videos

Last Updated: Dec 9, 2025

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

1.7K
The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

7.8K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.9K

Area of Science:

  • Space Biology
  • Molecular Mechanisms
  • Circadian Rhythms

Background:

  • Rodent models are crucial for studying spaceflight's molecular effects on human tissues.
  • NASA GeneLab offers valuable spaceflight omics data for biological insights.

Purpose of the Study:

  • To investigate space biological mechanisms across tissues using reanalyzed mouse RNA-sequencing data.
  • To elucidate the impact of spaceflight on clock gene expression and circadian rhythms.

Main Methods:

  • Reanalysis of mouse RNA-sequencing data from NASA GeneLab.
  • Comparative analysis of gene expression between spaceflight and ground control mice.

Main Results:

  • Spaceflight significantly altered clock gene expression in mice.
  • Evidence suggests spaceflight induces circadian clock asynchrony in peripheral tissues.

Conclusions:

  • Spaceflight disrupts normal circadian rhythms, with implications for health.
  • Further research into space biology can inform countermeasures for terrestrial and extraterrestrial health issues.