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Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
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The central nervous system and heart failure
Mark Dayer1, David H MacIver1,2, Stuart D Rosen3,4
1Department of Cardiology, Musgrove Park Hospital, Taunton, TA1 5DA, UK.
Future Cardiology
|September 16, 2020
Summary
Chronic heart failure is a multisystem disease affecting the brain and central nervous system (CNS). This review details CNS structural and biochemical changes in heart failure patients.
Area of Science:
- Cardiovascular Medicine
- Neuroscience
Background:
- Chronic heart failure was historically viewed as solely a cardiac condition.
- Recent understanding recognizes heart failure as a multisystem disease.
- Known adaptations occur in nervous, respiratory, muscular, and gastrointestinal systems.
Purpose of the Study:
- To review central nervous system (CNS) structural changes in chronic heart failure.
- To summarize biochemical alterations in the CNS of heart failure patients.
- To discuss the clinical significance of these CNS changes.
Main Methods:
- Literature review of studies on chronic heart failure and CNS involvement.
- Analysis of documented structural and biochemical changes in the CNS.
- Synthesis of findings regarding the impact on heart failure patients.
Main Results:
- The central nervous system (CNS) is significantly affected in chronic heart failure.
- Specific structural and biochemical changes in the brain are observed.
- These CNS alterations are often under-recognized in clinical practice.
Conclusions:
- Chronic heart failure impacts multiple organ systems, including the brain.
- Understanding CNS changes is crucial for comprehensive heart failure management.
- Further research is needed to fully elucidate the importance of these findings.
Keywords:
CNScerebral blood flowchronic heart failurediffusion tensor imagingfunctional magnetic resonance imagingrenin-angiotensin-aldosterone systemsubclinical cerebral infarctionwhite matter hyperintensitiesMore Related Videos
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