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Pathophysiology and treatment strategies for COVID-19

Manoj Kumar1, Souhaila Al Khodor2

  • 1Research Department, Sidra Medicine, Doha, Qatar.

Journal of Translational Medicine
|September 16, 2020
PubMed

Insights

The COVID-19 pandemic, caused by SARS-CoV-2, is a global health crisis. This review covers Severe Acute Respiratory Syndrome coronavirus 2 pathophysiology, transmission, and explores potential COVID-19 treatments.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • The emergence of Coronavirus disease 2019 (COVID-19), attributed to the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), presents a significant global health challenge.
  • The escalating number of COVID-19 cases strains healthcare systems worldwide, underscoring the urgent need for effective therapeutic interventions.

Purpose of the Study:

  • To provide a comprehensive review of the pathophysiology of SARS-CoV-2.
  • To elucidate the transmission dynamics of COVID-19.
  • To explore and summarize potential treatment strategies for SARS-CoV-2 infection.

Main Methods:

  • Literature review of scientific articles and research papers on SARS-CoV-2.
  • Analysis of data on COVID-19 transmission patterns.
  • Synthesis of information regarding current and emerging treatment options.

Main Results:

  • Detailed examination of the molecular mechanisms and cellular interactions of SARS-CoV-2.
  • Identification of key routes and factors influencing COVID-19 transmission.
  • Overview of various therapeutic approaches, including antiviral drugs and supportive care.

Conclusions:

  • Understanding SARS-CoV-2 pathophysiology and transmission is crucial for controlling the pandemic.
  • Further research into novel treatment strategies is essential to combat COVID-19 effectively.
  • A multi-faceted approach combining prevention, diagnostics, and therapeutics is vital for managing the ongoing health threat.

Keywords:
2019 novel coronavirusACE-2 receptorPandemicReceptor binding proteinSARS-CoV-2Viral inhibitor

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