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Updated: Dec 8, 2025

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
[Expert consensus on neonatal pain assessment and analgesia management (2020 edition)]
Insights
Neonates experience pain more intensely and for longer than adults. Standardized pain management, including step-by-step approaches, is crucial for their well-being and recovery.
Area of Science:
- Neonatal care
- Pediatric pain management
Background:
- Neonates exhibit heightened and prolonged pain perception compared to adults.
- Pain in neonates can lead to long-term negative physical and psychological effects.
- Effective pain management is vital for neonatal recovery and development.
Purpose of the Study:
- To develop an expert consensus on neonatal pain evaluation and management.
- To standardize analgesic measures for neonates in clinical practice.
- To provide evidence-based recommendations for managing neonatal pain.
Main Methods:
- Review of clinical evidence from China and internationally.
- Incorporation of clinical experience from neonatologists.
- Development of a step-by-step pain management protocol.
Main Results:
- Mild pain: gentle touch, non-nutritive sucking, and sucrose feeding are effective.
- Moderate pain: appropriate needle selection, skilled puncture, and local anesthetics are recommended.
- Severe pain: intravenous sedatives may be necessary, though evidence is limited.
Conclusions:
- A tiered approach to neonatal pain management is recommended.
- Non-pharmacological and pharmacological interventions should be tailored to pain severity.
- Further research is needed for optimal management of severe neonatal pain.
Abstract:
Compared with adults, neonates tend to have stronger and more persistent biological perception of pain. They may have the memory for pain and the negative effects caused by pain may exist for a long time. Therefore, standardized pain management can reduce or prevent the adverse effect of pain on body and mind and promote the rehabilitation process. In order to further deepen the understanding of pain management and standardize the analgesic measures for neonates, the Neonatologist Branch of Chinese Medical Association and Editorial Board of Chinese Journal of Contemporary Pediatrics have developed an expert consensus based on the clinical evidence in China and overseas and with reference to clinical experience from the following aspects: evaluation of neonatal pain and methods and techniques of pain management. It is recommended to adopt a step-by-step analgesic management for neonates. For mild pain stimulation, it is effective to relieve the pain by gentle touch and non-nutritive sucking combined with sucrose feeding. For moderate pain, selection of appropriate trocar needle and skilled puncture are important to reduce the pain, and in addition, the application of local anesthetics at the site of puncture also has a good effect. For severe pain, intravenous sedative drugs are often required, but no consistent evidence has been obtained so far.
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