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Tetrabromobisphenol A (TBBPA): A controversial environmental pollutant
Hui Zhou1, Nuoya Yin1, Francesco Faiola1
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.
Journal of Environmental Sciences (China)
|September 16, 2020
Summary
Tetrabromobisphenol A (TBBPA), a common flame retardant, may be safe for adults but warrants caution regarding its effects on early development. Further research is needed to fully understand TBBPA toxicity.
Area of Science:
- Environmental Science
- Toxicology
- Chemistry
Background:
- Tetrabromobisphenol A (TBBPA) is a widely used brominated flame retardant found globally.
- Concerns exist regarding TBBPA's potential adverse health effects due to its detection in humans and the environment.
- Exposure routes include diet, respiration, and skin contact.
Purpose of the Study:
- To re-evaluate published toxicological assessments of TBBPA.
- To determine the potential toxicity of TBBPA.
- To provide a conclusion on TBBPA safety.
Main Methods:
- Review of existing in vivo and in vitro toxicological studies.
- Analysis of data on TBBPA's multifaceted effects and potential organ toxicities.
- Evaluation of human exposure levels and metabolism.
Main Results:
- TBBPA has demonstrated multifaceted cellular and animal effects, including potential hepatic, renal, neural, cardiac, and reproductive toxicities.
- Some studies suggest TBBPA may be a safe chemical.
- Low exposure levels and rapid metabolism in humans are noted.
Conclusions:
- TBBPA may be safe for the general population due to low exposure and rapid metabolism.
- Particular attention is required for the potential effects of TBBPA on early developmental stages.
- Further investigation into developmental toxicity is warranted.
Keywords:
Developmental toxicityEndocrine disrupting chemicals (EDC)HepatotoxicityNeurotoxicityTetrabromobisphenol A (TBBPA)More Related Videos
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