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Related Experiment Video

Updated: Dec 8, 2025

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
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Sinister sinusitis.

James Robert Brighouse1, Kathryn Shepherd2, Rui Santos3

  • 1Paediatric Rheumatology, Evelina London Children's Hospital, London, UK james.brighouse@nhs.net.

Archives of Disease in Childhood. Education and Practice Edition
|September 16, 2020
PubMed
Summary
This summary is machine-generated.

Two teenage girls presented with severe sinusitis refractory to antibiotics, developing systemic symptoms and requiring intensive care. Both were diagnosed with the same rare condition and recovered well after treatment.

Keywords:
nephrologyrheumatology

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Area of Science:

  • Pediatric Critical Care Medicine
  • Infectious Diseases
  • Otolaryngology

Background:

  • Two previously healthy teenage girls presented with sinusitis unresponsive to antibiotic therapy.
  • Symptoms progressed despite broad-spectrum antibiotics, leading to multi-system involvement and intensive care unit admission.

Purpose of the Study:

  • To report a rare cause of severe sinusitis in adolescents.
  • To highlight the diagnostic challenges and clinical course of this condition.

Main Methods:

  • Case report detailing the clinical presentation, diagnostic workup, and treatment of two teenage patients.
  • Review of investigations including imaging and laboratory tests (details in Table 1, not provided in abstract).

Main Results:

  • Both patients exhibited progressive sinusitis with systemic manifestations including epistaxis, myalgia, arthralgia, fatigue, weight loss, and respiratory compromise.
  • One patient required intubation and mechanical ventilation, while the other progressed to venovenous extracorporeal membrane oxygenation (VV-ECMO).
  • Both patients were diagnosed with the same condition and achieved an excellent recovery.

Conclusions:

  • Severe sinusitis in adolescents, refractory to antibiotics, can indicate a serious underlying condition requiring intensive care.
  • Prompt diagnosis and appropriate management are crucial for favorable outcomes in such cases.