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Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
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Genome engineering technologies in rabbits.

Jun Song1, Jifeng Zhang1, Jie Xu1

  • 1Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

Journal of Biomedical Research
|September 16, 2020
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Summary
This summary is machine-generated.

Genome editing technologies like CRISPR/Cas9 are revolutionizing rabbit research. These advanced tools enable precise genetic modifications, overcoming previous limitations and paving the way for new disease models.

Keywords:
base editinggene targetinggenome editingrabbittransgenic animal

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Area of Science:

  • * Animal models and genetics
  • * Biomedical research and biotechnology

Background:

  • * Rabbits are valuable research models due to their size and evolutionary relation to primates.
  • * Previous genome manipulation techniques in rabbits were limited, hindering research applications.
  • * Advances in genome editing have been slow for decades in rabbit models.

Purpose of the Study:

  • * To review the historical development of transgenic rabbit technology.
  • * To summarize the advancements in novel genome editing technologies for rabbits.
  • * To highlight the potential of these technologies in creating disease models.

Main Methods:

  • * Review of historical and recent scientific literature on rabbit transgenesis and genome editing.
  • * Analysis of the impact of CRISPR/Cas9 and other novel technologies.
  • * Comparative assessment of genome editing efficiencies and applications.

Main Results:

  • * Novel genome editing technologies, particularly CRISPR/Cas9, have significantly improved precise genome manipulation in rabbits.
  • * These technologies offer superior capabilities compared to older methods.
  • * Successful generation of genetically modified rabbits for research purposes.

Conclusions:

  • * CRISPR/Cas9 and related technologies have overcome previous limitations in rabbit genome engineering.
  • * Enhanced genome editing in rabbits promises to accelerate the development of models for human genetic diseases.
  • * The review underscores the renewed potential of rabbits as versatile models in biomedical research.