Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropathologic documentation of prenatal brain damage.

W G Ellis1, B W Goetzman, J A Lindenberg

  • 1Department of Pathology, University of California, Davis, School of Medicine 95616.

American Journal of Diseases of Children (1960)
|August 1, 1988
PubMed
Summary

Prenatal brain damage affects 25% of infants who die within 7 days. Early detection of fetal/maternal issues is crucial to prevent rising cerebral palsy rates despite improved neonatal care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Review: Vascular dementia: clinicopathologic and genetic considerations.

Neuropathology and applied neurobiology·2018
Same author

THE ETIOLOGY OF BERI-BERI.

British medical journal·2010
Same author

UNCURED RICE AS A CAUSE OF BERIBERI.

British medical journal·2010
Same author

The effects of age on rate of progression of Alzheimer disease and dementia with associated cerebrovascular disease.

Archives of neurology·2001
Same author

Hemodynamic effects of positive end-expiratory pressure during partial liquid ventilation in newborn lambs.

Journal of pediatric surgery·2001
Same author

Presynaptic congenital myasthenic syndrome due to quantal release deficiency.

Neurology·2001

Area of Science:

  • Neonatal Neuropathology
  • Perinatal Medicine
  • Pediatric Neurology

Background:

  • Prenatal brain damage, particularly affecting cerebral white matter, is a significant concern in neonates.
  • Identifying clinical predictors of prenatal brain injury in early neonatal deaths is challenging.

Purpose of the Study:

  • To determine the incidence of neuropathologic evidence of prenatal brain damage in infants dying within the first week of life.
  • To identify clinical and obstetric factors associated with prenatal brain injury.

Main Methods:

  • Retrospective neuropathologic examination of 89 infants who died within 7 days of age.
  • Correlation of neuropathologic findings with clinical data and pregnancy history.

Main Results:

Related Experiment Videos

  • Prenatal brain damage was identified in 25% of the infants studied (10 preterm, 12 term).
  • Clinical features like low Apgar scores, seizures, and intracranial hemorrhage did not reliably distinguish injured from uninjured infants.
  • Hydramnios was the only obstetric factor significantly associated with prenatal brain injury, specifically in term infants.

Conclusions:

  • Prenatal brain damage is present in a substantial proportion of early neonatal deaths.
  • Improved neonatal care may lead to increased survival of prenatally damaged infants, potentially increasing the incidence of cerebral palsy.
  • Early identification and management of fetal/maternal abnormalities during late gestation are critical to mitigate long-term neurological deficits.