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Relationship of glycaemic derangement using continuous glucose monitoring system with sleep pattern among children

Nouran Y Salah1, Amal Y Abido2, Hebatallah R Rashed3

  • 1Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Diabetes/Metabolism Research and Reviews
|September 16, 2020
PubMed

Insights

Children with type 1 diabetes (T1D) experience disrupted sleep. Nocturnal hyperglycemia increases light sleep and sleep onset latency, while hypoglycemia deepens sleep.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Metabolic Disorders

Background:

  • Glycemic derangement is linked to sleep disruption.
  • The impact on sleep in children with type 1 diabetes (C-T1D) is not well understood.

Purpose of the Study:

  • To assess the effect of nocturnal hyperglycemia and clinically significant (CS) hypoglycemia on sleep patterns in C-T1D.

Main Methods:

  • Compared 30 C-T1D with 30 healthy siblings.
  • Utilized Continuous Glucose Monitoring System (CGMS) and polysomnography.
  • Excluded participants with other sleep-disrupting conditions or medications.

Main Results:

  • C-T1D showed lower sleep efficiency and higher arousal, periodic limb movement, and apnea-hypopnea indices.
  • Nocturnal hyperglycemia correlated with increased sleep onset latency and light sleep.
  • Clinically significant hypoglycemia was linked to deeper sleep stages.

Conclusions:

  • In C-T1D, CS hypoglycemia is associated with sleep deepening.
  • Hyperglycemia is linked to increased light sleep and prolonged sleep onset latency.
Abstract

Keywords:
continuous glucose monitoring systemglycaemic derangementsleep patternstype 1 diabetes

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