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Role of oncogenic REGγ in cancer

Maolei Shen1, Qinzhang Wang2, Shuaijun Xu3

  • 1Department of Urology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, Zhejiang, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 16, 2020
PubMed

Insights

REG gamma (REGγ) is a key player in human cancers, acting as a promising biomarker and therapeutic target. Targeting REGγ offers potential new diagnostic and treatment strategies for various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer presents significant global health challenges with limited treatment options.
  • REG gamma (REGγ), an 11S proteasome activator, is increasingly implicated in human cancer development.
  • A comprehensive understanding of REGγ's role in cancer is currently lacking.

Purpose of the Study:

  • To summarize the association between REG gamma (REGγ) and its role in multiple human cancers.
  • To highlight REGγ as a potential cancer biomarker and therapeutic oncotarget.
  • To discuss the molecular mechanisms underlying REGγ's function in tumorigenesis.

Main Methods:

  • Literature review of studies investigating REG gamma (REGγ) in cancer.
  • Analysis of REGγ's biological functions in cancer cell regulation.
  • Examination of signaling pathways activated by REGγ.

Main Results:

  • REG gamma (REGγ) expression is aberrantly linked to tumorigenesis through its regulation of cell cycle, proliferation, migration, invasion, angiogenesis, and metastasis.
  • REGγ functions via ATP- and ubiquitin-independent mechanisms.
  • REGγ acts as a molecular switch, activating oncogenic pathways like MAPK/p38, TGF-β/Smad, and Wnt/β-catenin.

Conclusions:

  • REG gamma (REGγ) is a promising oncotarget and biomarker for various human cancers.
  • Targeting REGγ presents potential for novel cancer diagnostics and therapeutics.
  • Understanding REGγ's mechanisms offers new avenues for cancer treatment strategies.
Keywords:
BiomarkerCancerOncogenePathogenesisREGγ

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