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Updated: Dec 8, 2025
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Effect of COVID-19 on platelet count and its indices
Ertuğrul Güçlü1, Havva Kocayiğit2, Hüseyin Doğuş Okan1
1. Sakarya University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Sakarya, Turkey.
Insights
Low oxygen saturation and increased Mean Platelet Volume (MPV) in COVID-19 patients are significant predictors of mortality. Monitoring MPV may aid in assessing COVID-19 severity and patient outcomes.
Area of Science:
- Hematology
- Infectious Diseases
- Critical Care Medicine
Background:
- Accessible laboratory tests are crucial for assessing COVID-19 severity.
- Platelet parameters like count, Mean Platelet Volume (MPV), and distribution width are widely available.
- Investigating their relationship with COVID-19 mortality is important for clinical practice.
Purpose of the Study:
- To explore the association between COVID-19 mortality and platelet count, MPV, and platelet distribution width.
- To identify potential laboratory markers for predicting mortality in COVID-19 patients.
Main Methods:
- Retrospective analysis of 215 COVID-19 patients.
- Patients categorized into moderate (oxygen saturation ≥90%) and severe (oxygen saturation <90%) groups.
- Statistical analysis using SPSS, with p<0.05 considered significant.
Main Results:
- Oxygen saturation at admission and MPV changes during hospitalization significantly predicted mortality.
- Patients with oxygen saturation <90% had 8.4 times higher mortality.
- A 1-unit increase in MPV correlated with a 1.76 times increased mortality risk.
Conclusions:
- Mean Platelet Volume (MPV) can serve as an auxiliary marker for predicting COVID-19 mortality.
- MPV, alongside lung capacity assessments, can enhance prognostic evaluations in COVID-19 patients.
Background:
Easily accessible, inexpensive, and widely used laboratory tests that demonstrate the severity of COVID-19 are important. Therefore, in this study, we aimed to investigate the relationship between mortality in COVID-19 and platelet count, Mean Platelet Volume (MPV), and platelet distribution width.
Methods:
In total, 215 COVID-19 patients were included in this study. The patients were divided into two groups. Patients with room air oxygen saturation < 90% were considered as severe COVID-19, and patients with ≥90% were considered moderate COVID-19. Patient medical records and the electronic patient data monitoring system were examined retrospectively. Analyses were performed using the SPSS statistical software. A p-value <0.05 was considered significant.
Results:
The patients' mean age was 64,32 ± 16,07 years. According to oxygen saturation, 81 patients had moderate and 134 had severe COVID-19. Our findings revealed that oxygen saturation at admission and the MPV difference between the first and third days of hospitalization were significant parameters in COVID-19 patients for predicting mortality. While mortality was 8.4 times higher in patients who had oxygen saturation under 90 % at hospital admission, 1 unit increase in MPV increased mortality 1.76 times.
Conclusion:
In addition to the lung capacity of patients, the mean platelet volume may be used as an auxiliary test in predicting the mortality in COVID-19 patients.
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