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Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

Interleukin-17 and ischaemic stroke.

Qiaohui Zhang¹, Yan Liao¹, Zhenquan Liu²

¹Chinese Medical Institute, Beijing University of Chinese Medicine, Beijing, China.

|September 16, 2020

Summary

This summary is machine-generated.

Interleukin-17 (IL-17) cytokines promote inflammation and worsen outcomes in ischaemic stroke. Understanding IL-17

Keywords:

IL-17A inflammation interleukin-17 (IL-17)stroke therapy

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Area of Science:

Immunology
Neurology
Pathophysiology

Background:

Interleukin-17 (IL-17) is a cytokine family with pro-inflammatory roles.
IL-17 signaling is implicated in autoimmune diseases like rheumatoid arthritis and multiple sclerosis.
Ischaemic stroke involves complex pathophysiological processes where inflammation contributes to poor prognosis.

Purpose of the Study:

To review the pathological modulation of the IL-17 family in ischaemic stroke.
To elucidate the mechanisms by which IL-17 contributes to stroke pathology.
To explore potential therapeutic insights targeting IL-17 in stroke.

Main Methods:

Literature review focusing on IL-17 family members and their receptors (IL-17Rs).
Analysis of inflammatory factors and immune cell involvement in post-stroke injury.
Synthesis of current understanding of IL-17's role in cerebral ischaemia.

Main Results:

IL-17 family members are involved in promoting inflammatory responses post-ischaemic stroke.
IL-17 signaling contributes to secondary injury following cerebral ischaemia.
The precise functions of IL-17 in stroke pathogenesis require further elucidation.

Conclusions:

IL-17 plays a significant role in the inflammatory processes and secondary damage associated with ischaemic stroke.
Further research into IL-17 mechanisms is crucial for developing novel stroke therapies.
Targeting IL-17 pathways may offer new therapeutic strategies for improving stroke outcomes.