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Bioorthogonal chemistry enables unnatural reactions in living organisms. This minireview updates advancements in animal studies for biological insights, imaging, and therapeutics.

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Area of Science:

  • Chemical biology
  • Bioorganic chemistry
  • Molecular imaging

Background:

  • Bioorthogonal chemistry provides tools for complex applications.
  • Performing unnatural reactions in vivo is a key goal in chemical biology.
  • Recent advancements enable novel in vivo chemical manipulations.

Purpose of the Study:

  • To provide an updated overview of bioorthogonal reactions in animal models.
  • To highlight applications in understanding biological processes.
  • To showcase innovative imaging and therapeutic strategies.

Main Methods:

  • Review of recent literature on in vivo bioorthogonal chemistry.
  • Focus on reactions conducted within animal subjects.
  • Analysis of applications in biological research and medicine.

Main Results:

  • Demonstration of diverse bioorthogonal reactions in animal models.
  • Advancements in visualizing and manipulating biological systems in vivo.
  • Development of new imaging probes and therapeutic modalities.

Conclusions:

  • Bioorthogonal chemistry is a powerful platform for in vivo applications.
  • Continued innovation is expanding the scope of chemical biology in animals.
  • These tools are crucial for future biological discovery and medical treatments.