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Related Concept Videos

Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
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Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
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Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
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Versatile Types of Cyclodextrin-Based Nucleic Acid Delivery Systems.

Chen Xu1, Bingran Yu1, Yu Qi1

  • 1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.

Advanced Healthcare Materials
|September 16, 2020
PubMed
Summary
This summary is machine-generated.

Cyclodextrin (CD)-based systems offer advanced nucleic acid delivery for cancer therapy. This review details CD-based strategies for gene therapy, focusing on nanohybrids for potential clinical use.

Keywords:
cyclodextringene therapynucleic acid deliveryorganic/inorganic nanohybridsupramolecular self-assembly

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery

Background:

  • Nucleic acid therapy shows promise for treating malignant diseases.
  • Cyclodextrin (CD)-based delivery systems are gaining attention due to CD's favorable properties.
  • Various CD-based systems are being developed for flexible gene therapies.

Purpose of the Study:

  • To review the construction strategies of CD-based nucleic acid delivery systems.
  • To discuss the biomedical applications of these advanced delivery systems.
  • To highlight the potential of CD-based nanohybrids for clinical translation.

Main Methods:

  • Review of synthesis and properties of CD-grafted polycations.
  • Detailed discussion of CD-related supramolecular assemblies.
  • Demonstration of CD-based organic/inorganic nanohybrids and their functions.

Main Results:

  • Exploration of diverse CD-based architectures for nucleic acid delivery.
  • Analysis of supramolecular assemblies and nanohybrids.
  • Identification of key strategies for system design.

Conclusions:

  • CD-based systems offer versatile platforms for nucleic acid delivery.
  • Further design of these systems could lead to significant clinical advancements.
  • Nanohybrid structures show particular promise for targeted gene therapy applications.