Related Experiment Video
Updated: Dec 8, 2025
Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse
Published on: April 27, 2019
Retracted: Treatment of Left Ventricular Circulation Disorder: Application of Echocardiography Information Data
Yulong Chen1, Jianxia Du1, Xiao Sun1
1Department of Ultrasound, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China.
Insights
Pressure overload causes cardiac hypertrophy, a heart failure cause. Removing pressure load reversed left ventricular changes, showing echocardiography
Area of Science:
- Cardiovascular Physiology
- Medical Imaging
- Surgical Innovation
Background:
- Cardiac hypertrophy from pressure overload is a key factor in heart failure and sudden cardiac death.
- Limited research exists on left ventricular remodeling and function post-pressure load removal.
Purpose of the Study:
- To simulate left ventricular (LV) structural and functional changes during pressure overload and subsequent unloading.
- To evaluate the utility of echocardiography in monitoring these dynamic LV changes.
Main Methods:
- Established ascending aorta constriction and deconstriction models in male BALB/C mice.
- Utilized echocardiography and hemodynamic examinations for comprehensive data collection.
Main Results:
- Constriction significantly increased LV dimensions (LVESD, LVEDD, IVS, LVPW) and diastolic pressure.
- Deconstriction led to significant decreases in LV dimensions, with earlier reversal being more pronounced.
- Maximal rate of LV pressure increase significantly decreased post-constriction.
Conclusions:
- Successfully established mouse models for ascending and descending aorta coarctation.
- Echocardiography is valuable for monitoring left ventricular circulatory disorders and assessing surgical outcomes.
Background:
Cardiac hypertrophy induced by pressure overload is one of the important causes of heart failure and sudden cardiac death. At present, there are few studies on the outcome of left ventricular hypertrophy and left ventricular function after complete pressure load removal.
Objective:
This study aims to better simulate the changes of left ventricular structure and function during the process of left ventricular pressure overload and deloading, and to explore the application of echocardiography in it.
Methods:
In this study, healthy male (BALB/C) mice were used as research objects to establish an ascending aorta constriction model, to carry out echocardiographic and hemodynamic examinations, to establish an ascending aorta deconstriction model in mice, and to carry out echocardiographic and hemodynamic examinations.
Results:
Compared with the sham operation group, the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), interventricular septal (IVS), and left ventricular posterior wall (LVPW) in the constriction operation group were significantly increased (P=.02, P=.02, P=.02, and P=.02, respectively). LVESD, LVEDD, IVS, and LVPW in the early and late constriction groups were significantly decreased, and the degree of decrease in the early group was greater than that in the late group; compared with the sham operation group, left ventricular diastolic pressure in the constriction operation group increased significantly at 9 and 15 weeks after operation (P=.03). Left ventricular systolic pressure at 15 weeks after operation decreased to a certain extent but was higher than that of the sham operation group (P=.02). The maximal rate of the increase of left ventricular pressure at 3 weeks, 9 weeks, and 15 weeks after operation decreased significantly (P=.03, P=.02, and P=.02, respectively).
Conclusions:
In this study, the ascending aorta coarctation model and descending aorta coarctation model were successfully established, which verifies the value of echocardiography information data monitoring in the treatment of left ventricular circulation disorders and the evaluation of surgical treatment.
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