[Upper urinary tract urothelial cell carcinoma].
A J Gross1, C Netsch2, J-U Stolzenburg3
1Abteilung für Urologie, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Deutschland. an.gross@asklepios.com.
Der Urologe. Ausg. A
|September 16, 2020
Summary
Upper urinary tract urothelial cell carcinoma (UTUC) is rare, often diagnosed late due to nonspecific symptoms. Radical nephroureterectomy (RNU) is standard, but bladder cancer recurrence necessitates close follow-up.
Area of Science:
- Urology
- Oncology
Background:
- Upper urinary tract urothelial cell carcinoma (UTUC) is a rare cancer with low incidence.
- Nonspecific clinical signs often delay early diagnosis of UTUC.
- The male-to-female incidence ratio for UTUC is approximately 2.5:1.
Purpose of the Study:
- To review the current diagnostic and therapeutic strategies for UTUC.
- To highlight the importance of follow-up care due to high recurrence rates.
Main Methods:
- Computed tomography urography (CTU) is a key diagnostic tool.
- Diagnostic ureterorenoscopy (URS) is essential for UTUC diagnosis.
- Radical nephroureterectomy (RNU) remains the primary surgical treatment.
Main Results:
- Early diagnosis of UTUC is challenging due to nonspecific symptoms.
- CTU combined with URS represents the gold standard for UTUC diagnostics.
- RNU involves removing the kidney and ureter, including a bladder cuff.
Conclusions:
- While RNU is standard, minimally invasive approaches are emerging.
- High rates of urothelial carcinoma recurrence within the bladder (22-47%) mandate vigilant post-RNU surveillance.
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