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Related Experiment Video

Updated: Dec 8, 2025

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Terminal complement complex formation is associated with intervertebral disc degeneration.

Graciosa Q Teixeira1, Zhiyao Yong1, Raquel M Goncalves1,2,3,4

  • 1Institute of Orthopaedic Research and Biomechanics, Trauma Research Centre, Ulm University, Ulm, Germany.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
|September 16, 2020
PubMed
Summary
This summary is machine-generated.

Terminal complement complex (TCC) deposition correlates with disc degeneration (DD). This inflammatory marker may be a therapeutic target for DD and early skeletal development.

Keywords:
Back painComplement systemInflammationInnate immunityScoliosis

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Area of Science:

  • Immunology
  • Orthopedics
  • Cell Biology

Background:

  • The complement system is vital for innate immunity.
  • Emerging research highlights its role in tissue homeostasis and degeneration.
  • This study focuses on the complement system's role in human disc degeneration.

Purpose of the Study:

  • To investigate the deposition of terminal complement complex (TCC) and its inhibitor CD59 in human disc tissues.
  • To correlate TCC and CD59 deposition with the degree of disc degeneration (DD).
  • To explore TCC's role in both degeneration and early skeletal development.

Main Methods:

  • Disc biopsies from patients with DD, adolescent idiopathic scoliosis (AIS), and healthy young and elder donors were analyzed.
  • Immunohistochemistry was used to detect TCC and CD59 in nucleus pulposus (NP), annulus fibrosus (AF), and endplate (EP).
  • TCC and CD59 levels were correlated with age, Pfirrmann grade, and Modic changes.

Main Results:

  • TCC+ cells were higher in the NP and EP of DD patients compared to elder controls and in the EP of young versus elder donors.
  • In DD, TCC deposition positively correlated with Pfirrmann grade.
  • TCC deposition showed a negative correlation with age in young donors, suggesting a role in early skeletal development. CD59 positivity was higher in AIS and DD groups.

Conclusions:

  • Terminal complement complex (TCC) deposition is positively associated with the severity of disc degeneration.
  • TCC may play a functional role in DD, presenting a potential therapeutic target.
  • The findings suggest TCC's involvement in both disc degeneration and early skeletal development.